Location: This position is field based and requires 60-80% travel.
The Opportunity
Praxis is seeking a field-based Clinical Trial Liaison (CTL) to partner directly with clinical trial sites and drive high-quality, high-urgency study execution. This is a hands-on, field-facing role focused on building trusted relationships with investigators and site staff, delivering scientific and protocol expertise, and addressing the real-world challenges that impact trial performance.
You will play a critical role across the lifecycle of study execution, from site initiation and training through enrollment and retention, while proactively identifying risks and working cross-functionally to resolve them. This is not a passive support role; you are expected to take ownership of site performance, think critically, and act with urgency to drive results.
We are open to hiring across levels and seek individuals who can operate with a high degree of ownership in the field, whether growing into the role or already leading independently. Leveling will reflect experience, judgment, and demonstrated ability to influence trial outcomes.
Success in this role requires strong clinical credibility, clear and effective communication, and the ability to operate autonomously in a high-travel, fast-paced environment.
Primary Responsibilities
- Serve as the primary scientific and operational lead for assigned clinical trial sites, driving engagement, performance, and accountability in partnership with Clinical Operations and CRO partners.
- Deliver protocol, disease state, and investigational product training to site personnel, ensuring strong study execution and clear understanding of expectations.
- Proactively identify risks to patient recruitment, retention, and protocol adherence—and own mitigation strategies in collaboration with cross-functional teams.
- Develop and execute investigator and site engagement plans to strengthen relationships and optimize trial performance.
- Identify, evaluate, and activate new clinical trial sites, including expanding high-performing networks and accelerating enrollment timelines.
- Represent Praxis at medical and scientific congresses, bringing back insights to inform trial strategy and execution.
- Maintain deep, current knowledge of CNS/neurology landscapes and competitive development, translating insights into actionable recommendations.
- Support adherence to regulatory requirements and Praxis policies and SOPs.
Qualifications and Key Success Factors
- Advanced clinical or scientific degree (PharmD, PhD, MD, NP, PA, or RN)
- Experience in clinical research, clinical care, or field-based roles supporting clinical trials
- Demonstrated ability to interpret and communicate complex scientific and clinical information with clarity and credibility
- Strong ownership mindset with the ability to operate independently, navigate ambiguity and drive results
- Comfort operating in a high-travel (~60–80%), field-based environment
- Proven ability to manage multiple priorities with strong organizational skills, attention to detail and follow-through
- Experience in neurology or CNS disorders preferred
- Candidates with prior field-based experience and a demonstrated track record of independently driving site performance, influencing investigators, and improving trial execution will be considered at a higher level.
The physical and mental requirements of our roles include but are not limited to regular use of a computer, devices or other office equipment, clear communication, and occasional movement. You'll need comfort with screen work, basic hand coordination, and focus. Reasonable accommodations may be made to enable individuals with disabilities to perform these functions.
Compensation & Benefits
At Praxis, we believe that taking care of our people (and their people) is important, so we provide a world class benefits package to help you thrive. This includes 99% of the premium paid for medical, dental and vision plans. We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future? We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP. We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns. Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring. We aim high, collaborate hard, and produce results. Let’s achieve the impossible together!
To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below. This range reflects the base salary the Company reasonably expects to pay for the position at the time of posting. Placement within the range will be based on job-related factors, including experience, qualifications, scope of responsibilities, and demonstrated track record of delivering results in similar roles.
Company Overview
Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance. At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders. Our core Values of Trust, Ownership, Curiosity and Results are foundational to every aspect of our business and are exemplified by each and every one of our team members.
Diversity, Equity & Inclusion
Guided by our core values, at Praxis Precision Medicines, Inc. we continue to DARE FOR MORE® to advance, promote, and champion diversity, equity, and inclusion by encouraging individuals to bring their authentic selves and perspectives to work each day. We are an equal opportunity employer and committed to providing opportunities to all qualified applicants without regard to race, religious creed, color, gender identity or expression, age, national origin, sexual orientation, disability, genetics, military service and veteran status, or any other characteristic protected by federal, state, or local laws.
Attention: Job Scam Alert
Praxis has recently become aware of fraudulent job recruitment postings from individuals claiming to represent Praxis. These postings seek financial information in connection with fraudulent opportunities for employment. If you suspect any fraudulent activity or misrepresentation in connection with a Praxis job opportunity, please report it to careers@praxismedicines.com.
Praxis does not accept unsolicited submissions from recruitment agencies for open positions. We ask all recruitment agencies to refrain from contacting any Praxis employee regarding any position. All unsolicited resumes submitted by recruitment agencies to any Praxis employee in any form or method will be deemed to be the property of Praxis, and Praxis explicitly reserves the right to hire those candidate(s) without any financial obligation to the recruitment agency.
